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Prolonging the survival of patients with gastric cancer

“The results of the study are important for cancer research. They show that patients with gastric cancer who have been…

By Staff , in Oncology , at May 8, 2023 Tags:

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“The results of the study are important for cancer research. They show that patients with gastric cancer who have been treated with zolbetuximab live longer. The progression of the tumour disease is delayed and overall survival of patients is improved. We expect that the study will lead to the approval of this drug in Europe and as a result also in Germany. This is an important step for those affected by this serious and often fatal cancer,” said Professor Florian Lordick, director of the University Cancer Center Leipzig. The experienced oncologist helped to design the recently published study at the international level and ensured that German patients were able to participate.

In this study with participants from 20 countries, a total of 565 patients were treated with  zolbetuximab in combination with chemotherapy or a placebo and chemotherapy. The test substance was developed in Germany more than ten years ago and has since been thoroughly researched through all study phases until it was ready for clinical use in patients. In the current study, treatment with zolbetuximab and chemotherapy significantly reduced the risk of disease progression or death by 25 per cent compared to patients treated with chemotherapy alone. The aim of the study was therefore achieved. The most common adverse events among participants were nausea, vomiting and decreased appetite, but overall the side effects of the combination of zolbetuximab and chemotherapy proved to be manageable.

Furthermore, the study establishes a new clinically relevant biomarker in gastric cancer called claudin-18 isoform 2 (CLDN18.2). This biomarker can be identified using a staining method in tumour biopsies, a procedure to remove cells or tissue from an affected area. If 75 per cent of the tumour cells stain positive for the membrane protein CLDN18.2, the drug zolbetuximab is likely to work particularly well. Zolbetuximab is given as an intravenous infusion to patients with advanced gastric cancer in combination with chemotherapy. It then docks via the bloodstream to the tumour cells carrying CLDN18.2, where it triggers an immune response that contributes to the death of the tumour cells.

“Following the introduction of trastuzumab ten years ago, this is the second targeted antibody that can prolong the survival of patients with advanced gastric cancer, and I have been privileged to play a key role in its clinical development,” said Professor Lordick.

This article is based on a press release from Universität Leipzig.

Staff
The team at The Medical Dispatch

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