A team of scientists from around the globe, including those from Trinity College Dublin, has gained high-res structural insights into a key bacterial enzyme, which may help chemists design new drugs to inhibit it and thus suppress disease-causing bacteria. Their work is important as fears continue to grow around rising rates of antibiotic resistance.
The scientists, led by Martin Caffrey, Fellow Emeritus in Trinity’s School of Medicine and School of Biochemistry and Immunology, used next-gen X-ray crystallography and single particle cryo-electron microscopy techniques to “look under the bacterial bonnet” and produce a molecular blueprint of the full-length enzyme that may be used to design drugs that attack any structural weaknesses.
Because the enzyme Lnt is not found in humans – it only exists in bacteria and helps them build stable cell membranes through which things are transported in and out of cells – it is of huge potential significance as a therapeutic target as any bespoke drug designed to attack it should have fewer side-effects for patients.
The research has just been published in leading international journal Science Advances.
This article is based on a press release from Trinity College Dublin.