A medical therapy that inhibits the growth of cancer cells may one day be effective at treating Lyme disease, according to new research by a University of Massachusetts Amherst team at the New England Regional Center of Vector-borne Diseases (NEWVEC).
“It’s a long way from something you’re going to pick up at CVS, but these early findings are very encouraging,” says vector-borne disease expert Stephen Rich, professor of microbiology, executive director of NEWVEC and senior author of the study published in the journal Pathogens.
Lyme disease is the most common vector-borne disease in the U.S., spread by infected deer ticks. The potentially debilitating illness, which is diagnosed in about 476,000 people each year in the U.S., doesn’t always respond to antibiotics.
“There are people who have cases of Lyme disease that go on and on,” Rich says. “So there’s always interest in finding new therapies or new ways to inhibit the growth of the bacterium. And based on what we’re seeing in the lab, this may be one of those ways.”
And in fact, in in vitro experiments, they did. “…a range of commercially available LDH inhibitors with various mechanisms of action and origins were tested on Borrelia in Culture,” the paper states. “Of these inhibitors, gossypol, AT-101, and oxamate substantially impacted B. burgdorferigrowth in vitro and represent promising candidates against Borrelia infections in vivo.”
Rich says the research will continue at NEWVEC, which was funded by the Centers for Disease Control and Prevention last year with a $10 million award to prevent and reduce tick- and mosquito-borne diseases in New England. NEWVEC aims to bring together academic communities, public health practitioners, residents and visitors across the Northeast, where Lyme infections are concentrated.
“These experiments were done outside of hosts. Now we need to carry this out in mouse models and, eventually, in people,” Rich says.
The researchers note that this drug therapy may also be effective against another tick-borne disease, babesiosis, a malaria-like infection. “This has the potential to kill two birds with one stone,” Rich says. “And that makes this discovery even more tantalizing.”
This article is based on a press release from the University of Massachusetts Amherst.